Importance of Purity Evaluation and the Potential of Quantitative1H NMR as a Purity Assay

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Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

In any biomedical and chemical context, a truthful description of chemical constitution requires coverage of both structure and purity. This qualification affects all drug molecules, regardless of development stage (early discovery to approved drug) and source (natural product or synthetic). Purity assessment is particularly critical in discovery programs and whenever chemistry is linked with b...

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Correction to Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay

Supporting Information SI‐1 The Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay Guido F. Pauli,1,2* Shao‐Nong Chen,1 Charlotte Simmler,1 David C. Lankin,1 Tanja Gödecke,1 Birgit U. Jaki,1,2 J. Brent Friesen,1,2,3 James B. McAlpine,1,2 and José G. Napolitano1,2 1Department of Medicinal Chemistry and Pharmacognosy and 2Institute for Tuberculosis Research...

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ژورنال

عنوان ژورنال: Journal of Medicinal Chemistry

سال: 2014

ISSN: 0022-2623,1520-4804

DOI: 10.1021/jm500734a